Replying to this about the storyline of Prototype.
SPOILERS!!!!!!!!!!
Prototype starts out as Alex Mercer, a man who, when he wakes up, knows that his name is Alex mercer and that he was a scientist. Over time, and many plotlines later, he finds that he was an experiment. As time continues, he controls his powers of the bio virus that infects him. But there is another virus loose on the city that is turning people into monsters.
It would be hard to make an RP of it unless most of the people were soldiers because only 2 people were ever exposed to the Blacklight virus.