My setup is a bit janky, but it seems to work fine.
OS: Windows 10 Enterprise LTSC 22H2 (2021)
RAM: 32GB Corsair Vengeance 2133MHz (4x8GB)
CPU: Intel i5-8600K
GPUs: AMD Radeon RX6700 XT 12GB, NVIDIA GeForce GTX 1070 Ti 8GB
Motherboard: MSI Z370-A PRO (MS-7B48)
Disks: Samsung 970 EVO Plus 1TB NVMe SSD, Samsung 860 EVO 500GB SATA SSD
Keyboard: ASUS ROG STRIX SCOPE (Evangelion Edition)
Mouse: Logitech G502
Microphone: Audio Technica AT-2020-USB+
Headphones: Sony WH1000-XM4
Monitors: ASUS VG279Q1A (1080p@144hz), LG 24ML600M (1080p@60hz)
A lot of people seem to take issue with my dual GPU configuration. I, personally, haven't run into any issues. My primary GPU is the Radeon GPU, which is the one my monitors are plugged into. The NVIDIA GPU is used entirely for GPU offloading tasks (NVENC and video rendering) so is idle most of the time.